Antiviral Efficacy of Favipiravir against Two Prominent Etiological Agents of Hantavirus Pulmonary Syndrome
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چکیده
منابع مشابه
Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques
BACKGROUND Despite repeated outbreaks, in particular the devastating 2014-2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JIKI trial) but did not demonstrate a strong antiviral efficacy. In order to ga...
متن کاملTreatment of hantavirus pulmonary syndrome.
Viruses in the genus Hantavirus can cause one of two serious illnesses when transmitted from rodents to humans: hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Of the two diseases, HPS is more severe with an approximate 40% mortality across the Americas. The high rate of mortality could be reduced if effective therapeutics could be discovered for treatment o...
متن کاملHantavirus pulmonary syndrome.
Hantavirus pulmonary syndrome (HPS) is a severe disease characterized by a rapid onset of pulmonary edema followed by respiratory failure and cardiogenic shock. The HPS associated viruses are members of the genus Hantavirus, family Bunyaviridae. Hantaviruses have a worldwide distribution and are broadly split into the New World hantaviruses, which includes those causing HPS, and the Old World h...
متن کاملHantavirus pulmonary syndrome.
Hantavirus pulmonary syndrome, also known as hantavirus cardiopulmonary syndrome, is a recently described infectious syndrome found throughout the Americas. Although infection is sporadic and uncommon compared with other atypical pneumonia syndromes, its high mortality rate warrants the maintenance of a high index of suspicion in rural settings. Because no specific therapies are available for t...
متن کاملHantavirus pulmonary syndrome.
An outbreak of Hantavirus Pulmonary Syndrome (HPS) occurred in the western U.S. in 1993. This outbreak was surprising because serious disease due to hantavirus had not been reported previously in the U.S., and hantavirus had not been documented to cause significant pulmonary disease. Epidemiologic investigation discovered a novel strain of hantavirus as the etiologic agent of HPS. The Centers f...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2013
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00886-13